Table 1.
Summary of the effects of fenofibrate and tesaglitazar in male and female B6 and B6 × 129S4 mice.
| Test | Males | Females | |||||
|---|---|---|---|---|---|---|---|
| Treatment | Fenofibrate (150 mg/kg) |
Tesaglitazar (1.5 mg/kg) |
Fenofibrate (150 mg/kg) |
Tesaglitazar (1.5 mg/kg) |
|||
| Genotype | B6 × 129 | B6 | B6 × 129 | B6 | B6 | B6 | |
| 2BC (saccharin) |
Preference | = | = | = | = | ||
| Total intake | = | ↑ | = | = | |||
| CPP | Acquisition | = | = | ||||
| Novelty | ↓ | ↓ | = | = | |||
| CTA | Acquisition | ↑ | = | ↑ | = | ||
| Acute withdrawal |
Above basal |
↑ | ↑ | ↑ | ↑ | = | = |
| Below basal |
↓ | ↓ | = | ↓ | ↓ | ↓ | |
| Startle response |
↓ | = | |||||
| LORR | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | |
| Metabolism | Clearance | ↑ | ↑ | = | ↑ | ||
| 2BC – continuous |
Ethanol (g/kg/24h) |
↓↓ | ↓↓↓ | = | ↓ | ||
| Preference | ↓↓ | ↓↓↓ | = | ↓ | |||
| Total fluid intake (g/kg/24h) |
= | ↑↑ | = | ↑ | |||
| 2BC – intermittent |
Ethanol (g/kg/24h) |
↓ | ↓ | ||||
| Preference | ↓ | ↓ | |||||
| Total fluid intake (g/kg/24h) |
= | = | |||||
2BC, two-bottle choice; CPP, conditioned place preference; CTA, conditioned taste aversion; LORR, loss or righting reflex; =, ↓, ↑ indicate no change, decrease, or increase compared to control. Data from 2BC-continuous and 2BC-intermittent drinking are from the companion manuscript (Blednov et al., in press.).