Table 3. Pathways associated with a decrease with age.
Metabolic pathways enriched for individual time points and the longitudinal analysis. Values reported are adjusted p-values from the metabolic pathway enrichment program mummichog. Pathways were considered significant if their adjusted p-values were less than 0.05. Tables of actual metabolites detected increasing with age and in the entire annotated metabolome shown in Table S2.
| Decrease with age | ||||||||
|---|---|---|---|---|---|---|---|---|
| Pathway | June 2012 | October 2012 | November 2013 | Longitudinal | ||||
| Females | Males | Females | Males | Females | Males | Females | Males | |
| Biopterin metabolism | 0.0014 | 0.0025 | ||||||
| Chondroitin sulfate degradation | 0.0025 | |||||||
| Dynorphin metabolism | 0.0004 | 0.0014 | 0.0025 | |||||
| Fatty acid activation | 0.0218 | |||||||
| Glycerophospholipid metabolism | 0.0319 | |||||||
| Glycine, serine, alanine and threonine metabolism | 0.0131 | 0.0118 | ||||||
| Glycosphingolipid biosynthesis - ganglioseries | 0.0112 | 0.0192 | ||||||
| Heparan sulfate degradation | 0.0025 | |||||||
| Histidine metabolism | 0.0235 | |||||||
| Leukotriene metabolism | 0.0035 | 0.0122 | ||||||
| Methionine and cysteine metabolism | 0.0215 | |||||||
| Prostaglandin formation from arachidonate | 0.0123 | |||||||
| Prostaglandin formation from dihomo gama-linoleic acid | 0.0025 | 0.0042 | ||||||
| Purine metabolism | 0.0118 | |||||||
| Pyrimidine metabolism | 0.0072 | |||||||
| Sialic acid metabolism | 0.0389 | |||||||
| Starch and Sucrose Metabolism | 0.0394 | 0.0126 | ||||||
| TCA cycle | 0.0093 | 0.0389 | ||||||
| Tryptophan metabolism | 0.0111 | 0.0032 | 0.0036 | 0.0287 | ||||
| Tyrosine metabolism | 0.0332 | 0.0218 | 0.0287 | |||||
| Valine, leucine and isoleucine degradation | 0.0160 | |||||||
| Vitamin A (retinol) metabolism | 0.0319 | |||||||
| Vitamin E metabolism | 0.0046 | 0.0389 | ||||||