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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Dec 17;1863(4):562–571. doi: 10.1016/j.bbamcr.2015.12.008

Fig. 8.

Fig. 8

Model of GCS-100 mediated killing. LGALS1 and LGAS3 mediate RAS signaling that support MCL-1 expression mediated by AKT and ERK. LGALS3 suppresses expression of p53 by an unknown mechanism. ABT-737 and ABT-199 inhibit BCL2, and GCS-100 inhibits LGALS1 and LGALS3.