Table 1.
Lung metastasis in nicotine-treated TRAMP mice
| Treatment | Tap water | Nicotine 100 μg/ml |
Nicotine 250 μg/ml |
|---|---|---|---|
| # of animals | 20 | 22 | 23 |
| Lung (number examined) | 20 | 22 | 23 |
| Lung metastasis |
-
(0%) |
6
*
(28%) |
7
*
(31%) |
| Adenocarcinoma with metastasis to the lung |
- (0%) |
1 (5%) |
2 (9%) |
| Neuroendocrine carcinoma with metastasis to the lung |
- (0%) |
5 (23%) |
5 (22%) |
| Lymph node (# examined) | 3 | 7 | 3 |
| Lymph node metastasis | - (0%) |
2** (29%) |
1** (33%) |
| Urogenital tract weight (mg) without seminal vesicles*** | |||
| 592 ± 231 | 513 ± 195 | 532 ± 462 | |
*
P = 0.046; Fisher’s exact test for trend;
**
neuroendocrine histology;
***
not significantly different between groups in both the animal weight-adjusted and unadjusted analysis ((ANOVA test).