Table 4.

Mean diagnostic likelihood ratios (SD) of other negative risk markers for coronary heart disease and cardiovascular disease events, adjusted for traditional risk factors and 10-year atherosclerotic cardiovascular disease predicted risk.

	All CHD Events		Hard CHD Events		All CVD Events
	Risk Factors*	ASCVD Risk†	Risk Factors*	ASCVD Risk†	Risk Factors*	ASCVD Risk†
Carotid Intima-Media Thickness ≤ 25th Percentile	0.65 (0.04)	0.53 (0.03)	0.78 (0.04)	0.64 (0.03)	0.75 (0.04)	0.61 (0.03)
No Carotid Plaque	0.84 (0.07)	0.77 (0.06)	0.88 (0.06)	0.81 (0.05)	0.88 (0.06)	0.81 (0.05)
Flow-Mediated Dilation ≥ 5% Change	0.94 (0.10)	0.90 (0.08)	0.86 (0.16)	0.81 (0.04)	0.91 (0.15)	0.87 (0.10)
Ankle-Brachial Index > 0.9 – < 1.3	0.98 (0.02)	0.98 (0.01)	0.97 (0.03)	0.95 (0.02)	1.00 (0.02)	0.99 (0.01)
HsCRP < 2mg/L	0.90 (0.03)	0.91 (0.02)	0.98 (0.01)	0.96 (0.01)	0.89 (0.04)	0.87 (0.03)
Homocysteine < 10µmol/L	0.96 (0.02)	0.90 (0.03)	0.94 (0.03)	0.89 (0.03)	0.96 (0.02)	0.91 (0.03)
NT-ProBNP < 100pg/mL	0.86 (0.10)	0.92 (0.04)	0.79 (0.12)	0.83 (0.05)	0.88 (0.09)	0.90 (0.04)
No Microalbuminura	0.96 (0.05)	0.95 (0.05)	0.97 (0.05)	0.96 (0.04)	0.97 (0.05)	0.95 (0.05)
No Family History of CHD (any)	0.76 (0.07)	0.76 (0.06)	0.78 (0.08)	0.77 (0.07)	0.81 (0.06)	0.80 (0.05)
No Family History of Premature CHD	0.97 (0.08)	0.96 (0.06)	0.99 (0.01)	0.96 (0.05)	0.96 (0.07)	0.95 (0.05)
No Metabolic Syndrome	0.90 (0.08)	0.85 (0.04)	0.91 (0.08)	0.87 (0.03)	0.91 (0.08)	0.85 (0.04)
Healthy Lifestyle	0.90 (0.13)	0.84 (0.04)	0.87 (0.08)	0.81 (0.01)	0.98 (0.16)	0.90 (0.05)

^*Age, gender, smoking status, diabetes, total and HDL cholesterol, systolic blood pressure, hypertension medication use and race/ethnicity.

^†10-year atherosclerotic ASCVD risk, calculated using the ACC/AHA 2013 Pooled Cohort Equations.

CHD indicates coronary heart disease; CVD, cardiovascular disease; ASCVD, atherosclerotic cardiovascular disease; HsCRP, high sensitivity C-reactive protein; and NT-ProBNP, N-terminal pro-brain natriuretic peptide.