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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Trends Immunol. 2016 Feb 6;37(3):208–220. doi: 10.1016/j.it.2016.01.004

Figure 3. The effect of the tumor microenvironment on the metabolism of myeloid cells.

Figure 3

Lactic acid produced by tumor cells and IL-4 produced by Th2 cells in the TME can drive the metabolism of TAM and TADC towards oxidative phosphorylation (oxphos) while inhibiting glycolysis. Lipids are known to have a role in negative regulation of TADC function. MDSC in peripheral tissue have decreased rates of oxphos and glycolysis compared to tumor-infiltrating MDSC (T-MDSC). Fatty acids derived from the TME drive the metabolism of T-MDSC towards fatty acid oxidation (FAO) and oxphos. Glycolytic rates are also increased in T-MDSC but how the TME influences this process, and the role AMPK plays in this process is unclear.