Table 1.

Demographic data and frequency/extent of skin and joint involvement at initial evaluation

	CS alone	D-pen plus CS	p values*	Average
Male:Female ratio	4:2	7:3	1.00	11:5
Interval from first symptoms to diagnosis (months)**	8.5±7.9	15±18.9	0.34	12.7±15.7
Age (years)**	39.7±27.7	57.8±7.1	0.45	51±19
Extent of affected Body Surface Area (BSA)	29.2±17.1%	28±16%	0.46	27±19%
Lesions crossing joints	100%	90%	1.00	93.8%
Flexion contractures	100%	70%	0.25	81.25%

^*p: Comparison between CS alone vs. CS + D-Pen.

^**Values expressed in means± standard deviation.