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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Clin Cancer Res. 2015 Oct 12;22(5):1197–1210. doi: 10.1158/1078-0432.CCR-14-3379

Figure 5.

Figure 5

Effects of MM on cell cycle progression, senescence and apoptosis in MPM cells. (*, P < 0.05; **, P < 0.01; ***, P < 0.001.)

A). Propidium iodide staining demonstrating that 24 hour MM treatment induces dose dependent G0/G1 arrest in MPM cells.

B). ß-galactosidase staining assays demonstrating that 24 hour MM treatment induces dose dependent senescence in MES1 and MES7 cells.

C) and D). Apo-BrdU analysis demonstrating minimal apoptosis in MPM cells immediately following 24 hour MM exposure (C), but significant dose-dependent apoptosis 48 hours following drug treatment (D).