Table 3.
Odds ratios (95% CI) for colorectal adenoma according to intakes of calcium and magnesium stratified by rs11022858 genotype of PTH, the Tennessee Colorectal Polyp Study1–3
| PTH genotype (rs11022858) | All adenomas vs controls | Distal adenomas vs controls | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Calcium/magnesium | <1.7 | 1.7–2.6 | ≥2.6 | P-trend | <1.7 | 1.7–2.6 | ≥2.6 | P-trend | |
| All | Cases/Controls | 67/127 | 544/993 | 663/1699 | 42/127 | 321/993 | 396/1699 | ||
| OR (95% CI) | 1.00 | 1.11(0.80–1.55) | 0.96(0.69–1.33) | 0.131 | 1.00 | 1.04(0.71–1.53) | 0.93(0.63–1.37) | 0.283 | |
| CC/TC | Cases/Controls | 54/111 | 460/840 | 571/1448 | 33/111 | 277/840 | 340/1448 | ||
| OR (95% CI) | 1.00 | 1.23(0.85–1.79) | 1.09(0.75–1.59) | 0.468 | 1.00 | 1.26(0.67–2.37) | 1.12(0.59–2.11) | 0.771 | |
| CC | Cases/Controls | 29/55 | 199/388 | 251/648 | 19/55 | 125/388 | 153/648 | ||
| OR (95% CI) | 1.00 | 1.19(0.70–2.02) | 1.09(0.64–1.85) | 0.795 | 1.00 | 1.36(0.71–2.62) | 1.17(0.60–2.25) | 0.601 | |
| TC | Cases/Controls | 25/56 | 261/452 | 320/800 | 14/56 | 152/452 | 187/800 | ||
| OR (95% CI) | 1.00 | 1.30(0.76–2.23) | 1.13(0.66–1.93) | 0.505 | 1.00 | 1.14(0.54–2.41) | 1.08(0.51–2.28) | 0.882 | |
| TT | Cases/Controls | 13/16 | 84/153 | 92/251 | 9/16 | 44/153 | 56/251 | ||
| OR (95% CI) | 1.00 | 0.74(0.31–1.74) | 0.52(0.22–1.23) | 0.040 | 1.00 | 0.61(0.23–1.63) | 0.53(0.20–1.41) | 0.248 | |
|
| |||||||||
| Total calcium intake (mg/d) | <600 | 600–1000 | ≥1000 | P-trend | <600 | 600–1000 | ≥1000 | P-trend | |
| All | Cases/Controls | 185/362 | 367/708 | 722/1749 | 111/362 | 220/708 | 428/1749 | ||
| OR (95% CI) | 1.00 | 0.95(0.74–1.22) | 0.74(0.56–0.98) | 0.0090 | 1.00 | 0.94(0.70–1.27) | 0.71(0.51–1.00) | 0.017 | |
| CC/TC | Cases/Controls | 141/303 | 322/592 | 622/1504 | 85/303 | 191/592 | 374/1504 | ||
| OR (95% CI) | 1.00 | 1.14(0.86–1.52) | 0.88(0.64–1.21) | 0.119 | 1.00 | 1.11(0.79–1.57) | 0.83(0.56–1.23) | 0.119 | |
| CC | Cases/Controls | 60/146 | 132/260 | 287/685 | 35/146 | 85/260 | 177/685 | ||
| OR (95% CI) | 1.00 | 1.19(0.78–1.83) | 1.01(0.63–1.62) | 0.719 | 1.00 | 1.30(0.77–2.19) | 1.05(0.59–1.89) | 0.795 | |
| TC | Cases/Controls | 81/157 | 190/332 | 335/819 | 50/157 | 106/332 | 197/819 | ||
| OR (95% CI) | 1.00 | 1.09(0.74–1.61) | 0.81(0.52–1.26) | 0.115 | 1.00 | 1.00(0.63–1.59) | 0.73(0.43–1.25) | 0.122 | |
| TT | Cases/Controls | 44/59 | 45/116 | 100/245 | 26/59 | 29/116 | 54/245 | ||
| OR (95% CI) | 1.00 | 0.43(0.23–0.80) | 0.36(0.18–0.74) | 0.012 | 1.00 | 0.49(0.23–1.05) | 0.38(0.16–0.91) | 0.040 | |
|
| |||||||||
| Total magnesium intake (mg/d) | <250 | 250–320 | ≥320 | P-trend | <250 | 250–320 | ≥320 | P-trend | |
| All | Cases/Controls | 219/492 | 192/434 | 863/1893 | 126/492 | 116/434 | 517/1893 | ||
| OR (95% CI) | 1.00 | 0.96(0.74–1.23) | 0.80(0.62–1.04) | 0.080 | 1.00 | 1.01(0.74–1.38) | 0.83(0.60–1.14) | 0.191 | |
| CC/TC | Cases/Controls | 184/409 | 161/361 | 740/1629 | 106/409 | 96/361 | 448/1629 | ||
| OR (95% CI) | 1.00 | 0.89(0.67–1.19) | 0.73(0.54–0.97) | 0.026 | 1.00 | 0.96(0.68–1.36) | 0.79(0.55–1.13) | 0.168 | |
| CC | Cases/Controls | 68/183 | 73/178 | 338/730 | 37/183 | 47/178 | 213/730 | ||
| OR (95% CI) | 1.00 | 0.96(0.62–1.50) | 0.91(0.57–1.43) | 0.670 | 1.00 | 1.24(0.72–2.15) | 1.20(0.68–2.12) | 0.595 | |
| TC | Cases/Controls | 116/226 | 88/183 | 402/899 | 69/226 | 49/183 | 235/889 | ||
| OR (95% CI) | 1.00 | 0.86(0.59–1.27) | 0.62(0.42–0.92) | 0.013 | 1.00 | 0.83(0.52–1.33) | 0.60(0.38–0.97) | 0.032 | |
| TT | Cases/Controls | 35/83 | 31/73 | 123/264 | 20/83 | 20/73 | 69/264 | ||
| OR (95% CI) | 1.00 | 1.56(0.78–3.10) | 1.65(0.78–3.49) | 0.213 | 1.00 | 1.65(0.71–3.81) | 1.43(0.58–3.51) | 0.505 | |
Phase I + Phase II
Unconditional logistic regression models adjusting for age (continuous), sex, race (white, others), education (categorical), recruitment sites, body mass index (categorical), smoking status (former, current, never), alcohol drinking status (former, current, never), physical activity (yes, no), daily intakes of total energy, magnesium or calcium (continuous)
The P values for the interactions between calcium/magnesium intake ratio, calcium and magnesium intake (continuous) with rs11022858 genotype were 0.050, 0.239, 0.415 for all adenomas and 0.121, 0.209, 0.377 for distal adenomas.