Table 2.
Summary of outcomes of different RCTs
| Study (ref) | Arm | End points events (n/N) | |||||
|---|---|---|---|---|---|---|---|
| Clinical Leakage | Peto OR (95 % CI) |
Wound Infection | Peto OR (95 % CI) |
Mortality | Peto OR (95 % CI) |
||
| Hoffman, [36] | Drain | 1/28 | 1.15 (0.07, 18.88) | 4/28 | 2.41 (0.45, 12.86) | 0/28 | 0.15 (0.01, 2.45) |
| No drain | 1/32 | 2/32 | 2/32 | ||||
| Johnson, [39] | Drain | 6/49 | 1.18 (0.36, 3.93) | 10/49 | 1.20 (0.46, 3.15) | 2/49 1/57 |
2.31 (0.23, 22.87) |
| No drain | 6/57 | 10/57 | |||||
| Hagmueller, [35] | Drain | 1/60 | 6.58 (0.13, 333.8) | 2/60 | 1.74 (0.18, 17.16) | 1/60 | 0.88 (0.05, 14.36) |
| No drain | 0/53 | 1/53 | 1/53 | ||||
| Sagar, [33] | Drain | 8/94 | 1.45 (0.40, 5.23) | 9/94 | 1.61 (0.42, 5.98) | 9/94 | 3.25 (0.85, 12.41) |
| No drain | 3/51 | 3/51 | 1/51 | ||||
| Sagar, [38] | Drain | 5/52 | 2.29 (0.50, 10.58) | 3/52 | 12.7 (0.21, 75.9) | 3/52 | 0.92 (0.18, 4.76) |
| No drain | 2/48 | 0/48 | 3/48 | ||||
| Merad, [12] | Drain | 1/156 | 0.53 (0.05, 5.11) | 6/156 | 0.88 (0.29, 2.67) | 7/156 | 0.80 (0.29, 2.17) |
| No drain | 2/161 | 7/161 | 9/161 | ||||
| Merad, [34] | Drain | 6/247 | 1.95 (0.52, 7.29) | 10/247 | 0.70 (0.31, 1.59) | 8/247 | 0.79 (0.31, 2.02) |
| No drain | 3/245 | 14/245 | 10/245 | ||||
| Brown, [37] | Drain | 2/31 | 0.90 (0.12, 6.74) | 5/31 | 1.57 (0.36, 6.92) | 1/31 | 0.90 (0.05, 14.82) |
| No drain | 2/28 | 3/28 | 1/28 | ||||
The odds ratio represents the odds of an adverse event occurring in the non drain group compared with the drain group. Odds ratios >1 favor the non drain group, and the point estimate of the odds ratio is considered statistically significant at the p < 0.05 level only if the 95 % confidence interval (95 % CI) does not include the vertical bar at 1. The 95 % CIs always include 1, indicating that there were no statistically significant differences between two groups for any outcome.
n no. of events, N total no. of patients in study, OR odds ratio, CI confidence interval