Table 1.
Total | <8 years | 8 to 14 years | ≥15 years | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Female | Male | p | Female | Male | p | Female | Male | p | Female | Male | p | |
VM ± DS | VM ± DS | VM ± DS | VM ± DS | VM ± DS | VM ± DS | VM ± DS | VM ± DS | |||||
Anthropometric data | ||||||||||||
N | 68 | 93 | 9 | 13 | 29 | 50 | 30 | 30 | ||||
Age (years) | 16.2 ± 7.3 | 14.4 ± 6.2 | 0.08 | 6.8 ± 1.1 | 6.4 ± 0.9 | 0.38 | 11.8 ± 2.3 | 11.8 ± 1.9 | 0.93 | 23.4 ± 4.1 | 22.0 ± 3.8 | 0.20 |
Weight (kg) | 46.3 ± 16.8 | 47.5 ± 20.8 | 0.69 | 23.2 ± 5.3 | 20.9 ± 2.4 | 0.18 | 40.3 ± 12.7 | 39.8 ± 12.1 | 0.85 | 59.4 ± 10.6 | 72.0 ± 9.2 | <0.001 |
Height (m) | 1.50 ± 0.18 | 1.53 ± 0.23 | 0.49 | 1.22 ± 0.08 | 1.17 ± 0.07 | 0.15 | 1.46 ± 0.14 | 1.47 ± 0.14 | 0.81 | 1.63 ± 0.07 | 1.77 ± 0.06 | <0.001 |
Body mass index (Kg/m2) | 19.6 ± 3.9 | 19.1 ± 3.7 | 0.44 | 15.5 ± 2.0 | 15.2 ± 1.1 | 0.68 | 18.4 ± 3.0 | 18.0 ± 2.6 | 0.51 | 22.2 ± 3.5 | 22.9 ± 2.6 | 0.38 |
Hemodynamic parameters | ||||||||||||
Heart rate | 79 ± 11 | 74 ± 12 | 0.03 | 87 ± 3 | 85 ± 11 | 0.65 | 80 ± 12 | 74 ± 11 | 0.07 | 75 ± 10 | 68 ± 12 | 0.04 |
Peripheral blood pressure | ||||||||||||
Brachial SBP (mmHg) | 107 ± 10 | 110 ± 13 | 0.10 | 98 ± 5 | 97 ± 7 | 0.77 | 105 ± 7 | 106 ± 6 | 0.53 | 114 ± 11 | 125 ± 11 | <0.001 |
Brachial DBP (mmHg) | 61 ± 7 | 59 ± 8 | 0.20 | 60 ± 6 | 57 ± 7 | 0.44 | 59 ± 6 | 58 ± 6 | 0.39 | 64 ± 9 | 64 ± 7 | 0.74 |
Brachial PP (mmHg) | 46 ± 7 | 51 ± 10 | <0.001 | 39 ± 3 | 42 ± 6 | 0.22 | 46 ± 6 | 48 ± 6 | 0.07 | 49 ± 7 | 60 ± 10 | <0.001 |
Central blood pressure | ||||||||||||
Aortic SBP (mmHg) | 92 ± 10 | 95 ± 12 | 0.26 | 82 ± 6 | 83 ± 6 | 0.85 | 89 ± 8 | 90 ± 8 | 0.50 | 99 ± 10 | 107 ± 9 | <0.001 |
Aortic DBP (mmHg) | 63 ± 7 | 61 ± 7 | 0.18 | 61 ± 5 | 59 ± 7 | 0.43 | 61 ± 7 | 59 ± 6 | 0.21 | 68 ± 10 | 65 ± 8 | 0.19 |
Aortic PP (mmHg) | 28 ± 6 | 33 ± 10 | <0.001 | 21 ± 2 | 23 ± 5 | 0.34 | 28 ± 5 | 31 ± 7 | 0.04 | 31 ± 6 | 42 ± 9 | <0.001 |
Aortic pulse wave analysis | ||||||||||||
Augmented pressure (mmHg) | 2 ± 3 | 0 ± 3 | 0.01 | 2 ± 2 | 2 ± 2 | 0.32 | 1 ± 3 | 0 ± 3 | 0.35 | 2 ± 3 | −1 ± 4 | <0.001 |
Augmentation index 75 (%) | 6 ± 11 | 1 ± 12 | 0.00 | 15 ± 9 | 15 ± 9 | 0.99 | 6 ± 9 | 1 ± 10 | 0.04 | 6 ± 8 | −8 ± 5 | <0.001 |
AIx-to-height ratio | 4.6 ± 7.8 | 1.2 ± 8.4 | 0.01 | 12.4 ± 7.9 | 12.8 ± 8.5 | 0.92 | 4.5 ± 7.4 | 1.0 ± 6.8 | 0.04 | 2.6 ± 7.1 | −3.9 ± 5.2 | <0.001 |
SEVR | 128 ± 33 | 140 ± 33 | 0.02 | 113 ± 20 | 126 ± 20 | 0.17 | 119 ± 26 | 133 ± 32 | 0.05 | 141 ± 37 | 158 ± 30 | 0.07 |
Mode B ultrasound | ||||||||||||
Common carotid artery | ||||||||||||
Diastolic diameter (mm) | 5.6 ± 0.5 | 5.9 ± 0.7 | 0.02 | 5.0 ± 0.4 | 5.2 ± 0.6 | 0.27 | 5.6 ± 0.5 | 5.8 ± 0.7 | 0.12 | 5.9 ± 0.4 | 6.3 ± 0.5 | 0.01 |
IMT (mm) | 0.442 ± 0.046 | 0.459 ± 0.061 | 0.08 | 0.405 ± 0.039 | 0.416 ± 0.048 | 0.58 | 0.433 ± 0.036 | 0.449 ± 0.054 | 0.16 | 0.459 ± 0.044 | 0.497 ± 0.069 | 0.04 |
Elastic modulus (mmHg) | 252 ± 100 | 295 ± 138 | 0.05 | 134 ± 28 | 161 ± 40 | 0.11 | 220 ± 66 | 267 ± 101 | 0.03 | 349 ± 75 | 424 ± 137 | 0.04 |
β Index | 1.64 ± 0.22 | 1.75 ± 0.30 | 0.02 | 1.46 ± 0.15 | 1.50 ± 0.29 | 0.74 | 1.63 ± 0.20 | 1.70 ± 0.25 | 0.21 | 1.74 ± 0.21 | 1.98 ± 0.24 | <0.001 |
Common femoral artery | ||||||||||||
Diastolic diameter (mm) | 5.6 ± 1.1 | 6.3 ± 1.4 | <0.001 | 4.5 ± 0.8 | 4.6 ± 0.4 | 0.63 | 5.4 ± 0.8 | 6.0 ± 1.0 | <0.001 | 6.8 ± 0.7 | 7.8 ± 0.9 | <0.001 |
Elastic modulus (mmHg) | 803 ± 463 | 877 ± 599 | 0.45 | 484 ± 198 | 519 ± 194 | 0.70 | 725 ± 367 | 723 ± 366 | 0.98 | 1146 ± 547 | 1386 ± 803 | 0.32 |
β Index | 2.25 ± 0.19 | 2.21 ± 0.18 | 0.26 | 2.33 ± 0.17 | 2.37 ± 0.17 | 0.66 | 2.27 ± 0.18 | 2.20 ± 0.17 | 0.09 | 2.09 ± 0.16 | 2.11 ± 0.16 | 0.86 |
Regional arterial stiffness | ||||||||||||
Carotid-femoral PWV (m/s) | 4.9 ± 0.9 | 5.3 ± 1.1 | 0.05 | 4.5 ± 0.7 | 4.4 ± 0.6 | 0.88 | 4.7 ± 0.6 | 4.8 ± 0.6 | 0.21 | 5.6 ± 0.9 | 6.6 ± 1.0 | <0.001 |
βPWV Index | 0.62 ± 0.17 | 0.72 ± 0.26 | 0.01 | 0.56 ± 0.15 | 0.58 ± 0.17 | 0.74 | 0.57 ± 0.12 | 0.63 ± 0.15 | 0.10 | 0.75 ± 0.21 | 1.01 ± 0.26 | 0.01 |
Carotid-radial PWV (m/s) | 7.5 ± 1.1 | 7.8 ± 1.2 | 0.17 | 7.5 ± 1.1 | 7.8 ± 1.5 | 0.65 | 7.4 ± 1.2 | 7.6 ± 1.2 | 0.44 | 7.9 ± 1.0 | 8.7 ± 1.2 | 0.07 |
Data expressed as mean value (M) ± standard deviation (SD). SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; PWV, pulse wave velocity.