Table 2.
The top three enriched targets in clusters VII, X, and XII. It can be seen that, in many cases, the top three enriched targets are implicated in immunomodulation. Estimation Score = 0, for all top three enriched targets.
| TCM therapeutic action class | TCM therapeutic action subclass | Top three enriched targets | Target function reported by literatures | Average Score | |
|---|---|---|---|---|---|
| Cluster X | Wind-dampness dispelling | Bone (sinew) strengthening | DNA topoisomerase 1 | Cancer | 0.0144 |
| Sodium/glucose cotransporter 1 | Glucose homeostasis | 0.0342 | |||
| Steryl-sulfatase | Immunomodulation | 0.0370 | |||
| Tonifying and replenishing | Qi tonifying | Tyrosine-protein phosphatase nonreceptor type 2 | Immunomodulation | 0.0174 | |
| Sodium/glucose cotransporter 2 | Glucose homeostasis | 0.0282 | |||
| Sodium/glucose cotransporter 1 | Glucose homeostasis | 0.0321 | |||
| Cough suppressing and panting-calming | Clearing and heat phlegm resolving | Tyrosine-protein phosphatase nonreceptor type 2 | Immunomodulation | 0.0112 | |
| DNA topoisomerase 1 | Cancer | 0.0236 | |||
| Testosterone 17-beta-dehydrogenase 3 | Reproduction system | 0.0341 | |||
| Tranquilizing | Heat nourishing tranquilizing | Peptidyl-prolyl cis-trans isomerase FKBP1A | Immunomodulation | 0.0077 | |
| Tyrosine-protein phosphatase nonreceptor type 2 | Immunomodulation | 0.0167 | |||
| Glutamate carboxypeptidase 2 | CNS | 0.0209 | |||
|
| |||||
| Cluster VII | Heat-clearing medicinal | Heat-clearing and blood cooling | Protein kinase C beta type | Immunomodulation | 0.0100 |
| DNA topoisomerase 1 | Cancer | 0.0123 | |||
| Sodium/glucose cotransporter 2 | Glucose homeostasis | 0.0137 | |||
| Hemostatic medicinal | Stasis resolving hemostatic | Tyrosine-protein phosphatase nonreceptor type 2 | Immunomodulation | 0.0089 | |
| Protein kinase C eta type | Immunomodulation | 0.0182 | |||
| Protein kinase C gamma type | Immunomodulation | 0.0209 | |||
| Tonifying and replenishing | Blood tonifying | Tyrosine-protein phosphatase nonreceptor type 2 | Immunomodulation | 0.0140 | |
| Protein kinase C beta type | Immunomodulation | 0.0230 | |||
| Protein kinase C eta type | Immunomodulation | 0.0240 | |||
|
| |||||
| Cluster XII | Parasite destroying, dampness eliminating, and itchiness relieving | Dihydrofolate reductase | Cancer, bacterial infection | 0.0532 | |
| DNA-dependent protein kinase catalytic subunit | Cancer | 0.0644 | |||
| Tumour necrosis factor | Cancer, bacterial infection | 0.0687 | |||