Figure 6.

Intracellular calcium participates in desensitized α7-nAChR-mediated depression of the GABA_A receptor but is not involved in the potentiation of the NMDA receptor in cultured hippocampal neurons. Typical muscimol- (A) or NMDA- (C) evoked currents recorded before and after a choline pulse in normal or 10 mmol/L BAPTA-containing pipette solution. Corresponding bar graphs indicate the changes in muscimol- (B, n=5 cells) and NMDA- (D, n=5 cells) evoked currents after a choline pulse in varying pipette solutions. Data are shown as the mean±SEM. ^cP<0.01 vs the current after choline in normal pipette solution, Student's t-test. Cho, choline; Mus, muscimol; I_Mus, muscimol-evoked current; I_NMDA, NMDA-evoked current. Holding potential was −80 mV.