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In the cultured H9C2 cells subjected to the SIR treatment, BBR significantly attenuated the PERK/eIF2α/ATF4-mediated myocardial ER stress, whereas JAK2 siRNA abolished this effect. (A) Representative blots. (B) p-PERK/PERK ratio. (C) p-eIF2α/eIF2α ratio. (D) ATF4 expression. (E) CHOP expression. The results are expressed as the mean±SEM. n=8/group. cP<0.01 vs the SIR group; fP<0.01 vs the SIR+BBR group; iP<0.01 vs the SIR+BBR+JAK2 siRNA group.
