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. 2016 Jan 25;37(3):354–367. doi: 10.1038/aps.2015.136

Figure 5.

Figure 5

BBR up-regulated cardiac JAK2/STAT3 signaling and down-regulated myocardial apoptosis, whereas AG490 treatment blocked these effects. Normal rats pretreated with BBR or AG490 were subjected to the MI/R operation. All measurements were performed after 4 h of reperfusion. (A) Representative blots. (B) p-JAK2/JAK2 ratio. (C) p-STAT3/STAT3 ratio. (D) Caspase-3 expression. (E) Bcl-2 expression. (F) Bax expression. BBR, berberine; AG, AG490. The results are expressed as the mean±SEM. n= 8/group. cP<0.01 vs the MI/R+V group; fP<0.01 vs the MI/R+BBR group; iP<0.01 vs the MI/R+BBR+AG group.