Figure 3.

Antibody (Ab) levels to full-length VAR2CSA throughout pregnancy in individual women. Each line represents an individual woman. Solid line on the y axis represents cutoff for seropositivity (5,964 median fluorescence intensity [MFI]) based on Ab levels in males. The nonlinear trend lines were estimated with generalized additive mixed models with penalized B-spines. Vertical solid lines indicate the time point when half the women started taking sulfadoxine–pyrimethamine (22 weeks for primigravidae and 21 weeks for multigravidae).