Figure 1.
Trial flow chart. On days 8, 36, and 64 after initiation of chloroquine chemoprophylaxis, vaccine groups 1 and 3 received injections containing 7.5 × 104 Plasmodium falciparum sporozoites (PfSPZ), while control groups 2 and 4 received normal saline. On day 124, groups 1 and 2 underwent controlled human malaria infection (CHMI) with PfSPZ by mosquito bite. Groups 3 and 4 received additional PfSPZ injections on day 232 and underwent CHMI on day 369. BMI = body mass index; ECG = electrocardiogram.