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. 2016 Feb 26;60(3):1687–1694. doi: 10.1128/AAC.01801-15

TABLE 3.

Pharmacokinetic resultsa

Screening no. AUC0–8 (mg · h/liter) prefilter Cltot (liters/h) Clpre-post filter (ml/min) Sc ClSc (ml/min) V
 t1/2β (h)
Total (liters) Corrected for body wt (liters/kg)
1 71.96 9.53 23.26 0.123 3.32 57.75 0.65 4.19
2 58.65 7.42 30.61 0.146 5.09 135.90 1.76 12.69
3 67.50 8.93 35.75 0.272 9.41 76.82 0.85 5.96
4 89.89 9.00 26.61 0.184 6.26 41.56 0.42 3.20
5 81.58 7.62 33.12 0.195 6.50 54.37 0.72 4.94
6 84.32 6.93 47.23 0.153 5.09 41.55 0.26 4.15
7 95.28 7.53 69.65 0.168 7.26 40.87 0.58 3.76
8 87.59 5.14 29.97 0.064 2.30 59.22 0.70 7.98
9 81.64 8.24 24.24 0.104 2.97 51.15 0.51 4.30
10 71.95 11.31 20.70 0.176 4.51 51.71 0.86 3.13
11 —c —c 42.06 0.139 7.66 —c —c —c
13 79.02 5.53 57.98 0.089 3.63 61.22 0.60 7.67
14 73.62 9.73 33.63 0.128 6.12 39.01 0.52 2.78
Mean ± SD
    All patientsb 78.58 ± 10.32 8.07 ± 1.77 36.06 ± 14.27 0.150 ± 0.053 5.20 ± 1.95 59.26 ± 26.47 0.70 ± 0.36 5.39 ± 2.84
    Patients on CVVH (n = 3) 87.15 ± 8.13 6.53 ± 1.00 63.82 ± 5.83 0.129 ± 0.033 6.45 ± 1.81 51.05 ± 10.18 0.59 ± 0.01 5.72 ± 1.96
    Patients on CVVHD (n = 5) 77.59 ± 12.31 7.48 ± 1.43 34.03 ± 7.22 0.164 ± 0.067 5.63 ± 2.30 71.01 ± 34.98 0.80 ± 0.52 6.80 ± 3.37
    Patients on CVVHDF (n = 5) 76.15 ± 4.50 9.29 ± 1.28 26.99 ± 5.34 0.145 ± 0.035 4.68 ± 1.43 50.80 ± 6.34 0.65 ± 0.13 3.87 ± 0.80
a

Prefilter, measured in the blood before it enters the filter (concentrations are as found in the patient); Cltot, total body clearance; Clpre-post filter, clearance calculated by the hemofilter inlet/outlet-based formula described in Materials and Methods; Sc, sieving/saturation coefficient; ClSc, clearance calculation based on the sieving coefficient. The dose for each patient was 1 g doripenem q8h.

b

Except for patient 11, whose values were excluded from the calculation of means.

c

—, values for patient 11 have been excluded from calculation of means (absolute concentrations too low due to storage at -20°C). The same error may affect calculated values as the clearance and sieving coefficient values, which are given due to the fact that they are calculated as relative values.