TABLE 5.
Pharmacokinetic parameters of carbapenems reported in previous trials
| Carbapenem and publication | Cltot (liters/h) |
V |
t1/2β (h) | Cmax 0–8h (mg/liter) | Ctrough (mg/liter) | ClcRRT (liters/h) | |
|---|---|---|---|---|---|---|---|
| Total (liters) | Corrected for body wt (liters/kg) | ||||||
| Meropenem | |||||||
| Valtonen et al. (20) | 4.8–7.5 | 3.27–4.72 | |||||
| Thalhammer et al. (13) | 8.6 ± 1.2 | 29.5 ± 2.7 | 0.36 ± 0.1 | 2.3 ± 0.4 | 28.1 ± 2.5 | 6.6 ± 1.5 | 2.98 ± 0.5 |
| Isla et al. (21) | 9.0–63.9 | 0.4–1.3 | 1.5–3.7 | 30.4–43.3 | 1.0–7.7 | 1.0–1.9 | |
| Imipenem | |||||||
| Afshartous et al (15) | 5.3 ± 0.8 | 33.1 | 1.9–2.1 | ||||
| Fish et al. (12) | 8.7–10.7 | 35.2 ± 15.2 | 0.37 ± 0.10 | 1.5–2.0 | 15.6–17.8 | 1.1–1.4 | 2.2–3.4 |
| Doripenem | |||||||
| Cirillo et al. (3) | 4.9–6.0 | 28.2–29.6 | 0.297–0.343 | 3.87–4.24 | 18.9–24.1 | 1.3–1.5 | |
| Roberts et al. (4) | 4.46 | 38.0 | 1.34–1.84 | ||||