TABLE 3.
LDV is a specific inhibitor of HCV
| Virus | Description | Host cell line | EC50 (nM)b | CC50 (nM)b |
|---|---|---|---|---|
| HCV GT1b replicon | Hepacivirus (positive ssRNAc) | Huh-7 | 0.004 | >44,400 |
| BVDV replicon | Pestivirus (positive ssRNA) | Huh-7 | 19,300 | >50,000 |
| West Nile virus Kern 2002 | Flavivirus (positive ssRNA) | Vero | >100,000 | >100,000 |
| Yellow fever virus 17D | Flavivirus (positive ssRNA) | Vero | >100,000 | >100,000 |
| Dengue virus type 2 | Flavivirus (positive ssRNA) | Vero | >41,000 | 41,000 |
| Banzi virus | Flavivirus (positive ssRNA) | Vero | >100,000 | >100,000 |
| RSV | Paramyxovirus (negative ssRNA) | HEp-2 | >10,000 | >10,000 |
| Human rhinovirusa | Enterovirus (positive ssRNA) | HeLa | >50,000 | >50,000 |
| Influenza A virus PC/1/73 | Orthomyxovirus (negative ssRNA) | NHBE | >100,000 | >100,000 |
| Influenza B virus LEE/40 | Orthomyxovirus (negative ssRNA) | NHBE | >100,000 | >100,000 |
| HBV | Hepadnavirus (DNA reverse transcribing) | AD-38 | >10,000 | >10,000 |
| HIV | Lentivirus (RNA reverse transcribing) | MT-4 | >10,000 | 10,100 |
a
Infectious mixture of HRV1A, HRV16, and HRV14.
b
Values represent the arithmetic means from two or more independent experiments.
c
ssRNA, single-stranded RNA.