TABLE 1.
MICs of β-lactams for V. cholerae N14-02106, E. coli TOP10 harboring recombinant plasmid pVCC-1, and the E. coli TOP10 parent strain
| β-Lactam | MIC (μg/ml)a |
||
|---|---|---|---|
| V. cholerae N14-02106 | E. coli TOP10(pVCC-1)b | E. coli TOP10 | |
| Ceftriaxone | 0.39 | 1.5 | 0.064 |
| Cefotaxime | 0.064 | 0.38 | 0.094 |
| Ceftazidime | 0.75 | 3 | 0.75 |
| Cefoxitin | 16 | 12 | 6 |
| Cefepime | 1.5 | 0.5 | 0.094 |
| Aztreonam | >256 | 48 | 0.094 |
| Amoxicillin + CLAc | 16 | 64 | 4 |
| Piperacillin + TZBd | 48 | 32 | 1.5 |
| Imipenem | >32 | 12 | 0.5 |
| Meropenem | >32 | 2 | 0.047 |
| Ertapenem | >32 | 1.5 | 0.004 |
| Doripenem | >32 | 2 | 0.032 |
a
MICs were determined with Etest gradient strips.
b
pVCC-1 contains blaVCC-1 cloned into pCR-XL-TOPO.
c
CLA, clavulanic acid at a fixed concentration of 4 μg/ml.
d
TZB, tazobactam at a fixed concentration of 4 μg/ml.