FIG 1.

Identification of a compound with broad antifungal activity. (A) Selection of a new antifungal, sr7575, through a chemical library screen of A. fumigatus growth inhibition was followed by chemogenomic profiling in S. cerevisiae to identify a potential mechanism of action. (B to D) sr7575 inhibited growth of various fungi, including A. flavus (48 h, 37°C, RPMI medium, 5 μg/ml) (B), C. albicans and C. neoformans (24 h, 37°C, SC medium, 2 μg/ml) (C), and S. cerevisiae (48 h, 30°C, SC medium, 1 μg/ml) (D).