FIG 3.

Summary of mutations conferring increased susceptibility to sr7575. (A) Heatmap showing the unique ERAD signature of sr7575 compared with published chemogenomic and SGA growth defect profiles. (B) Model showing the two main pathways responsible for ERAD in fungi: the Doa10 pathway (green) for clearing misfolded proteins with cytosolic lesions and the Hrd1 pathway (violet), which degrades misfolded proteins with lumenal or transmembrane lesions. Shared components (Ubx2, Ubc7, Cue1, and the Cdc48 complex) are denoted in gray or black.