TABLE 2.
Population pharmacokinetic parameters of ICU-HD patients compared with those of ICU-85 patients (6)
| Parameter | Volume of distribution or clearance | ICU-HD patients |
ICU-85 (6)a |
||||
|---|---|---|---|---|---|---|---|
| Typical value (% RSE) | IIV, % CVb (RSE, %) | Residual Errors |
Typical value (% RSE) | IIV, % CV (% RSE) | |||
| Proportional % CV (% RSE) | Additive (mg/liter) (% RSE) | ||||||
| CMS | |||||||
| VCMS (liters) | Volume of distribution of CMS | 21 (13) | 24 (45) | 48 (12) | 0.11 (28) | 15.7 (7) | 44 (14) |
| CLRCMS (ml/min) | Renal clearance of CMS | 0 (fixed) | 0 (fixed) | 68.5 (12) | 72 (11) | ||
| CLNRCMS (ml/min) | Nonrenal clearance of CMS | 113 (14) | 31 (35) | 43.7 (11) | 42 (18) | ||
| Colistin | |||||||
| Vcol/fm (L) | Apparent volume of distribution of colistin | 28.3 (18) | 42 (36) | 15 (24) | 0.13 (27) | 10.2 (16) | 81 (15) |
| CLcol/fm (ml/min) | Apparent clearance of colistin | 33.3 (16) | 42 (29) | 37.7 (10) | 37 (15) | ||
| Renal replacement | |||||||
| CLHDCMS (ml/min) | Dialysis clearance of CMS | 90 (fixed) | |||||
| CLHDCOL (ml/min) | Dialysis clearance of colistin | 137 (fixed) | |||||
a
Typical value for a patient of 70 kg with a creatinine clearance of 85 ml/min.
b
CV, coefficient of variation.