TABLE 2.
Parameter estimates for levofloxacin from the final covariate 2-compartment population pharmacokinetic model
| Parametera | Mean | SD | Coefficient of variation (%) | Median |
|---|---|---|---|---|
| Clearance (liters/h) | 8.66 | 3.85 | 44.5 | 7.49 |
| Vcentral (liters) | 41.5 | 24.5 | 59.0 | 36.1 |
| kcp (h−1) | 2.58 | 3.51 | 136.0 | 1.30 |
| kpc (h−1) | 0.90 | 0.58 | 64.1 | 0.75 |
a
Vcentral, volume of distribution of the central compartment; kcp, rate constant for drug distribution from the central to the peripheral compartment; kpc, rate constant for drug distribution from the peripheral to the central compartment.