FIG 10.

Approximation of the moxifloxacin AUC (in milligrams per hour per liter) that suppresses the amplification of moxifloxacin-resistant subpopulations when the agent is administered as a continuous infusion (A) or once daily (B). For both panels, the number of resistant colonies (total population) at an AUC of zero was determined at time zero. Other colony counts were determined at the end of the experiment. The estimate of the resistance-suppressive AUC value is given by the intersection of the vertical line with the x axis. q24h, every 24 h. For B. anthracis, the AUC/MIC ratio is the dynamic index driving cell kill in this hollow-fiber infection model evaluation. For resistance suppression, the linked index switches to time at >MIC.