FIG 8.

Dose fractionation of total daily AUCs generated for linezolid (Lin) at 500 and 600 mg every 24 h (q24h). (A) Effects of each regimen, when given as one, two, or six equally divided doses each day, on the total B. anthracis population (Pop). (B to E) Effects of fractionation of the 600-mg dose of linezolid on total and resistant populations. (E) Effects of linezolid at 800 mg given once daily on these populations. The effects on resistance amplification of fractionating the 24-h AUC exposure generated for linezolid at 500 mg q24h are not shown. (A) The pharmacodynamic index linked to bacterial cell kill of B. anthracis by linezolid (first 4 days) is the AUC/MIC ratio in this hollow-fiber infection model evaluation. (B to E) For resistance suppression, the linked dynamic index switches to the peak/MIC ratio.