TABLE 1.
MIC results for ceftazidime, ceftazidime-avibactam, and imipenem or meropenem obtained against baseline aerobic Gram-negative pathogens recovered from the ME population
| Trial | Organism | Agenta | No. of isolates at MIC (μg/ml) of: |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | >32 | |||
| cIAI | Enterobacteriaceaeb | CAZ | 16 | 42 | 24 | 2 | 1 | 1 | 1 | 6 | 13 | 24 | ||
| CAZ-AVI | 19 | 52 | 36 | 11 | 4 | 3 | 4 | 1c | ||||||
| MER | 127 | 1 | 1 | 1c | ||||||||||
| Pseudomonas spp.d | CAZ | 1 | 6 | 1 | 2 | 1e | ||||||||
| CAZ-AVI | 1 | 1 | 6 | 1 | 1 | 1e | ||||||||
| MER | 1 | 2 | 2 | 2 | 2 | 1 | 1e | |||||||
| Acinetobacter spp.f | CAZ | 1 | 1 | 2g | ||||||||||
| CAZ-AVI | 1 | 1 | 1g | 1g | ||||||||||
| MER | 1 | 1 | 2g | |||||||||||
| cUTI | Enterobacteriaceaeh | CAZ | 2 | 4 | 22 | 6 | 3 | 3 | 3 | 2 | 5 | 5 | 8 | |
| CAZ-AVI | 8 | 17 | 28 | 9 | 1 | |||||||||
| IMI | 17 | 40 | 6 | |||||||||||
| P. aeruginosa | CAZ | 3 | ||||||||||||
| CAZ-AVI | 3 | |||||||||||||
| IMI | 1 | 2 | ||||||||||||
CAZ, ceftazidime; CAZ-AVI, ceftazidime-avibactam; MER, meropenem; IMI, imipenem.
Includes 103 E. coli isolates, 16 K. pneumoniae isolates, four K. oxytoca isolates, three E. cloacae isolates, and one isolate each of Citrobacter freundii, Citrobacter braakii, Enterobacter aerogenes, and P. mirabilis.
One NDM-1-producing K. pneumoniae isolate.
Includes eight P. aeruginosa isolates, two P. fluorescens isolates, and one P. stutzeri isolate.
Includes one VIM-2-producing P. aeruginosa isolate.
Includes three A. baumannii isolates and one A. junii isolate.
Includes one PER-1-producing A. baumannii isolate and one OXA-23-producing A. baumannii isolate.
Includes 59 E. coli isolates, two P. mirabilis isolates, and one isolate each of Citrobacter koseri and E. cloacae.