TABLE 3.
Summary of baseline aerobic Gram-negative pathogens recovered from patients in the ME population in the cIAI trials for ceftazidime-avibactama
| Pathogen(s) in each patient (no. of patients) | Result (no. of isolates [% within species])b |
|---|---|
| E. coli (91) | Screen negative (58 [63.7]) |
| Screen positive (33 [36.3]) | |
| CTX-M-15 (4) | |
| CTX-M-15 + SHV-12 (1) | |
| CTX-M-15 + OXA-1/30 + ACC-4 (1) | |
| CTX-M-15 + OXA-1/30 (14) | |
| CTX-M-15 + OXA-1/30 + CMY-42 (3) | |
| CTX-M-15 + OXA-1/30 + SHV-12 (1) | |
| CTX-M-15 + OXA-1/30 + SHV-2 (1) | |
| OXA-1/30 (1) | |
| SHV-12 (3) | |
| CMY-6 (1) | |
| CMY-42 (2) | |
| OXA-1/30 + CMY-42 (1) | |
| K. pneumoniae (12) | Screen negative (6 [60.0]) |
| Screen positive (6 [40.0]) | |
| CTX-M-15 (1) | |
| CTX-M-15 + OXA-1/30 (1) | |
| CTX-M-15 + OXA-1/30 + SHV-5 (1) | |
| NDM-1 + CTX-M-15 (1) | |
| Other screen positivec (2) | |
| C. braakii (1) | CTX-M-15 (1) |
| C. freundii (1) | Screen negative (1) |
| E. cloacae (3) | Screen negative (2) |
| Screen positive (1) | |
| E. aerogenes (1) | Screen negative (1) |
| K. oxytoca (2) | Screen negative (2) |
| P. mirabilis (1) | ACC-4 (1) |
| E. coli-K. pneumoniae (3) | Screen negative for E. coli (2) and K. pneumoniae (2) |
| CTX-M-15 + OXA1/30 + SHV-31 for E. coli (1) and CTX-M-15 for K. pneumoniae (1) | |
| E. coli-K. oxytoca (2) | Screen negative for E. coli (2) and K. oxytoca (2) |
| E. coli-A. baumannii (1) | CTX-M-15 for E. coli (1) and OXA-23 for A. baumannii (1) |
| P. aeruginosa (2) | Screen negative (1) |
| VIM-2 + OXA-4 + OXA-10 (1) | |
| P. aeruginosa-E. coli (4) | Screen negative for P. aeruginosa (4) and E. coli (4) |
| P. aeruginosa-A. junii (1) | Screen negative for P. aeruginosa (1) and A. junii (1) |
| P. aeruginosa-A. baumannii (1) | Screen negative for P. aeruginosa (1) and PER-1 for A. baumannii (1) |
| A. baumannii (1) | Screen negative (1) |
| P. fluorescens (1) | Screen negative (1) |
| P. fluorescens-E. coli-K. pneumoniae (1) | Screen negative for P. fluorescens (1), E. coli (1), and K. pneumoniae (1) |
| P. stutzeri-E. coli (1) | Screen negative for P. stutzeri (1) and E. coli (1) |
a
The cIAI results shown represent 130 ME patients.
b
Screen negative, isolates that did not meet the MIC-based screening criteria; screen positive, isolates that met the screening criteria (i.e., ceftriaxone and/or ceftazidime MICs of ≥2 μg/ml, NF-GNB with ceftazidime MICs of ≥16 μg/ml, and Enterobacteriaceae and NF-GNB isolates exhibiting imipenem and meropenem MICs of ≥2 and ≥16 μg/ml, respectively). CMY-42 is a single-amino-acid-change (V231S) variant of CMY-2.
c
Some isolates met the phenotypic MIC screening criteria, but targeted β-lactamase resistance mechanisms were not detected.