TABLE 3.
Clinical outcomes by CART-derived threshold group and in-hospital survival
| Parameter | Value(s) for each PK model of estimated exposure: |
|||||
|---|---|---|---|---|---|---|
| Model 1 |
Model 2 |
|||||
| fT>MIC ≤ 68 % | fT>MIC > 68 % | P valuea | fT>MIC ≤ 74 % | fT>MIC > 74 % | P valuea | |
| Total no. (%) of patients | 67 (37.2) | 113 (62.3) | 46 (25.6) | 134 (74.4) | ||
| Died, n (%) | 17 (25.4) | 8 (7.1) | 0.001 | 15 (32.6) | 10 (7.5) | <0.001 |
| ICU transfer postculture, n (%) | 26 (38.8) | 39 (34.5) | 0.56 | 19 (41.3) | 46 (34.3) | 0.40 |
| Hospital LOS postculture for survivors (n = 155), median (IQR) | 8.4 (5.9–18) | 9.1 (5.9–18) | 0.94 | 9.5 (6.0–21) | 8.9 (5.7–18) | 0.37 |
| ICU LOS postculture for survivors (n = 47), median (IQR) | 6.7 (2.0–13) | 3.0 (2.0–7.7) | 0.22 | 9.0 (2.0–16) | 3.0 (2.0–7.9) | 0.22 |
| Readmission within 30 days, n (%) | 15 (30.0) | 41 (39.1) | 0.27 | 10 (32.3) | 46 (37.1) | 0.62 |
| Inpatient total duration of antibiotics post culture, median (IQR) | 9.1 (5.2–17) | 8.6 (5.9–16.4) | 0.91 | 9.9 (5.9–21) | 8.4 (5.6–15.4) | 0.26 |
a
For categorical variables, P values are from Fisher's exact test when cell counts were from <6 observations.