TABLE 4.
Multivariate model of the contribution of cefepime fT>MIC to the odds of in-hospital survival
| Model parameter | Value(s) for each PK model of estimated exposurea: |
|||
|---|---|---|---|---|
| Model 1 (fT>MIC threshold of 68%) |
Model 2 (fT>MIC threshold of 74%) |
|||
| Univariate analysis, OR (95% CI) | Multivariate analysis, aOR (95% CI) | Univariate analysis, OR (95% CI) | Multivariate analysis, aOR (95% CI) | |
| Cefepime fT>MIC > threshold | 4.46 (1.80–11.0) | 7.12 (1.90–26.7) | 6.00 (2.46–14.6) | 6.48 (1.90–22.1) |
| Modified APACHE II (day 0) > 17.5 | 0.20 (0.08–0.49) | 0.08 (0.02–0.32) | 0.20 (0.08–0.49) | 0.11 (0.03–0.41) |
| Log10 days to positive culture | 0.19 (0.08–0.44) | 0.33 (0.12–0.96) | 0.19 (0.08–0.44) | 0.30 (0.03–0.89) |
| Receipt of prior immune suppressants (12 mo) | 0.26 (0.08–0.92) | 0.25 (0.05–1.15) | 0.26 (0.08–0.92) | 0.23 (0.05–1.11) |
| History of leukemia | 0.22 (0.08–0.57) | 0.17 (0.04–0.70) | 0.22 (0.08–0.57) | 0.16 (0.04–0.68) |
| ICU at time of culture | 0.15 (0.06–0.37) | 0.09 (0.02–0.31) | 0.15 (0.06–0.37) | 0.09 (0.03–0.33) |
a
Model 1, in-hospital survival according to an fT>MIC threshold of 68%. Model 2, in-hospital survival according to an fT>MIC threshold of 74%.