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. 2016 Feb 26;60(3):1736–1746. doi: 10.1128/AAC.01864-15

FIG 1.

FIG 1

Diversity of Tn5801-like elements, types A and B, based on strains used in this study and sequences deposited in the GenBank genome database. In silico comparative analysis was made using BLAST and MUSCLE software available at the BLAST (http://www.ncbi.nlm.nih.gov/blast//) and MUSCLE (http://www.ebi.ac.uk/Tools/msa/muscle/) websites. Dashed red lines, deletion sequences; red ORFs, ORFs encoding integrase-like proteins; dark blue ORFs, ORFs encoding replication proteins; light blue ORFs, ORFs encoding hypothetical proteins; green ORFs, tetracycline resistance gene tet(M); yellow ORFs, orf9 and orf21 are absent in Staphylococcus aureus Mu50 (reference genome) and orf13 in type B differs from orf13 in type A; brown ORFs, other resistance genes; purple ORFs, insertion sequences (IS). Wavy lines, recombination with Tn5397; straight lines, recombination with Tn916; diagonal lines, recombination with type A variant. ORFs with spots, B23 sequence differing from type B variants. dfrG, dihydrofolate reductase; LSA, lincosamides and streptogramins A; BcrA, bacitracin transport; Sag, Streptococcus agalactiae; Smi, Streptococcus mitis; Efs, Enterococcus faecalis; Efm, Enterococcus faecium; Sau, Staphylococcus aureus; Sps, Staphylococcus pseudintermedius. All IS correspond to IS families: IS1062 (IS30 family, A5), IS1542 (IS256 family, A6), IS1678 (IS1380 family, A7), ISEfa8 (IS3 family, A8), IS1542 (IS256 family; B19, B20, B21, and B22), ISLgar5/ISEfm2 (IS256 family, orf1).