TABLE 2.
Acquired resistance to fluconazole and anidulafungin in C. glabrata isolates from blood and swab samples
| Isolate group and parameter | Value for isolatesa |
||
|---|---|---|---|
| Oral (≥7 days)b | Blood (no exposure) | Oral (<7 days) | |
| Isolates with exposure to azoles | |||
| No. of isolates with fluconazole MIC above BP/total no. of isolates (%) | 10/34 (29.4) | 3/62 (4.8)<0.01 | 5/48 (10.4)<0.05 |
| Fluconazole geometric mean MIC (mg/liter) | 10.01 | 3.66<0.05 | 4.83<0.05 |
| Isolates with exposure to echinocandins | |||
| No. of isolates with anidulafungin MIC above BP/total no. of isolates (%) | 11/51 (21.6) | 3/62 (4.8)<0.01 | 1/31 (3.2)<0.05 |
| Anidulafungin geometric mean MIC (mg/liter) | 0.053 | 0.043NS | 0.048NS |
a
Superscript numbers indicate significant P values. NS, not significant. BP, EUCAST clinical breakpoint for resistance.
b
Reference column for statistical comparisons. Isolates were exposed to either azole or echinocandins for ≥7 days before a swab was obtained.