FIG 5.

Effects of new verapamil analogs on intracellular M. tuberculosis and M. tuberculosis-specific immunity. (A) Activities of selected analogs on intracellular M. tuberculosis. Each drug was used at a final concentration of 2.5 μM. KSV21 had significantly better activity than MKV4 (*, P < 0.05, Mann-Whitney U test). (B) Effects of new analogs on the expansion of M. tuberculosis-specific T cells. The experimental setup was similar to that described in the Fig. 3 legend. MKV9 at a concentration of 2.5 μM significantly inhibited M. tuberculosis-specific T cells (*, P < 0.05). Similar concentrations of MKV4 and KSV21 did not inhibit the expansion of M. tuberculosis-specific T cells. MR, medium rested. Results are shown as means ± standard errors.