TABLE 2.
Multivariable logistic regression model for clinical success
| Variable and value | Parameter estimate (SE) | Odds ratio (95% CId) | Likelihood ratio P value |
|---|---|---|---|
| CLCR (ml/min/1.73 m2) | <0.001 | ||
| ≤51.2a | 1 | ||
| >51.2 to ≤88.9 | 2.59 (1.18) | 13.3 (1.32–135) | |
| >88.9 | 4.30 (1.35) | 73.7 (5.21–1,042) | |
| AUC/MIC ratio | 0.091 | ||
| ≤1,081b | NE | NE | |
| >1,081 to ≤2,334a | 1 | ||
| >2,337 | 1.29 (0.94) | 3.64 (0.57–23.2) | |
| Albumin concn (g/dl) | 0.039 | ||
| <2.9a | 1 | ||
| ≥2.9 | 1.55 (0.78) | 4.70 (1.02–21.5) | |
| Diagnosis categoryc | 0.086 | ||
| 1a | 1 | ||
| 2, 3, or 4 | 1.85 (1.28) | 6.34 (0.52–77.2) | |
| 5 | 3.03 (1.48) | 20.8 (1.14–378) |
a
Represents the reference group.
b
With a 100% observed response (8/8) in the group with AUC/MIC ratios of ≤1,081, no estimates relative to this group could be obtained with maximum likelihood estimation. NE, not estimated.
c
Diagnosis category definitions are as follows: 1, left-sided endocarditis; 2, 3, or 4, complicated right-sided endocarditis, uncomplicated right-sided endocarditis, or complicated bacteremia, respectively; 5, uncomplicated bacteremia.
d
CI, confidence interval.