Table 2.
SNPs analyzed for association with cigarettes per day in WHI SHARe.
| SNP | Chromosome (base-pair) position | Nearby genes | Alleles | Coded Allele | Coded AF | ß (s.e.) | P-value | P-value (adjusted)* |
|---|---|---|---|---|---|---|---|---|
| rs1051730 | 15:78601997 | CHRNA3 | G/A | A | 0.13145 | 0.081 (0.029) | 0.00095 | 0.02669 |
| rs7180002 | 15:78581651 | CHRNA5 | A/T | T | 0.11941 | 0.072 (0.034) | 0.00307 | 0.08597 |
| rs951266 | 15:78586199 | CHRNA5 | G/A | A | 0.11944 | 0.069 (0.035) | 0.00383 | 0.10718 |
| rs2036527 | 15:78559273 | CHRNA5 | G/A | A | 0.22451 | 0.077 (0.029) | 0.00388 | 0.10872 |
| rs17486278 | 15:78575140 | CHRNA5 | A/C | C | 0.28691 | 0.072 (0.026) | 0.00492 | 0.13772 |
| rs16969968 | 15:78590583 | CHRNA5 | G/A | A | 0.08021 | 0.059 (0.036) | 0.00725 | 0.20295 |
| rs4243084 | 15:78619330 | CHRNA3 | G/C | C | 0.20197 | 0.072 (0.028) | 0.00745 | 0.20854 |
| rs17405217 | 15:78438807 | IREB2 | C/T | T | 0.09058 | 0.056 (0.033) | 0.01213 | 0.33967 |
| rs547843 | 15:26178900 | LOC503519 | C/G | G | 0.35954 | 0.068 (0.029) | 0.01740 | 0.48725 |
| rs938682 | 15:78604205 | CHRNA3 | A/G | G | 0.28587 | − 0.049 (0.025) | 0.02642 | 0.73971 |
| rs11852372 | 15:78509052 | HYKK | A/C | C | 0.16997 | 0.040 (0.029) | 0.03982 | 1 |
| rs478776 | 15:78596058 | CHRNA3 | A/G | G | 0.47358 | 0.029 (0.024) | 0.05376 | 1 |
| rs8031948 | 15:78523715 | HYKK | G/T | T | 0.18103 | 0.043 (0.028) | 0.05791 | 1 |
| rs10519203 | 15:78521704 | HYKK | A/G | G | 0.32025 | 0.042 (0.025) | 0.11335 | 1 |
| rs564585 | 15:78593885 | CHRNA3 | G/A | A | 0.47403 | 0.016 (0.026) | 0.12637 | 1 |
| rs17408276 | 15:78589276 | CHRNA5 | T/C | C | 0.1458 | − 0.062 (0.029) | 0.19065 | 1 |
| rs7164594 | 15:78510715 | HYKK | C/T | T | 0.40943 | − 0.020 (0.024) | 0.19103 | 1 |
| rs11637635 | 15:78584808 | CHRNA5 | G/A | A | 0.28379 | − 0.044 (0.026) | 0.19106 | 1 |
| rs3101457 | 1:244369912 | C1orf100 | A/G | G | 0.2478 | 0.072 (0.049) | 0.23023 | 1 |
| rs3813570 | 15:78540490 | PSMA4 | T/C | C | 0.27113 | − 0.027 (0.027) | 0.28473 | 1 |
| rs2735940 | 5:1296371 | TERT | G/A | A | 0.49586 | − 0.028 (0.033) | 0.32441 | 1 |
| rs17486195 | 15:78572855 | CHRNA5 | A/G | G | 0.13368 | 0.012 (0.029) | 0.33791 | 1 |
| rs8029939 | 15:78596007 | CHRNA3 | G/A | A | 0.12207 | 0.053 (0.035) | 0.34905 | 1 |
| rs4635969 | 5:1308437 | TERT | G/A | A | 0.31211 | 0.031 (0.025) | 0.40241 | 1 |
| rs667282 | 15:78571130 | CHRNA5 | T/C | C | 0.2945 | − 0.024 (0.026) | 0.48116 | 1 |
| rs7168796 | 15:78508152 | HYKK | T/C | C | 0.16283 | 0.048 (0.031) | 0.52338 | 1 |
| rs9672189 | 15:78509054 | HYKK | A/C | C | 0.15226 | 0.030 (0.028) | 0.69760 | 1 |
| rs684513 | 15:78566058 | CHRNA5 | C/G | G | 0.13145 | − 0.013 (0.031) | 0.89055 | 1 |
Legend: Abbreviations: AF, allele frequency; SNP, single-nucleotide polymorphism. Coded AF refers to the allele analyzed as the predictor allele; it is not necessarily the minor allele. All SNPs coded to NCBI Build 38/UCSC hg38 forward strand. *Bonferronni-adjusted P-value. Beta (ß) and standard error (s.e.) for change in CPD per increase in additive risk (increase in presence of coded allele.