Fig. 6.

Lung fibrosis in Mtb-infected rabbits with or without CC-11050 treatment at 12 weeks post infection. (a and e) Representative image of lung sections from Mtb infected untreated rabbits. Significant collagen deposition (blue staining) can be seen around the granulomas. (b and f) Representative image of lung sections from rabbits treated with INH alone. Significant collagen deposition (blue staining) surrounding the necrotic lesions can be seen in f. (c and g) Representative image of lung sections from rabbits treated with CC-11050 alone. Significantly less staining was observed in these granulomas. (d and h) Representative image of lung sections from rabbits treated with INH + CC-11050. Minimal amount of fibrosis can be visualized surrounding the granuloma in h. All sections were stained using Masson's trichrome method. Images a–d were photographed at 4 × (Scale bar = 500 μm) and e–h at 40 × magnification (Scale bar = 50 μm), respectively.