Fig. 2.
Oral phages reach the intestine in children hospitalized with acute bacterial diarrhea, but show no impact on quantitative clinical diarrhea outcomes.
Left: Mean and standard deviation for stool weight (measured without urine contamination) in g/day (A), stool frequency per day (B), and need for oral rehydration solution in ml/day to correct dehydration (C) for the specified day of hospitalization in children enrolled into the three treatment groups identified by the color code. No significant difference was detected between the treatment groups.
Right, D: Prevalence of phage positive stools (≥ 10 pfu/g stool on E. coli indicator strain K-12) at the indicated time points (D01–05: days 1 to 5 of hospitalization; D21: re-convalescent visit 21 days after hospital admission) in the three treatment groups; green: NRC T4-like phage cocktail (T), red: Russian Microgen phage cocktail (M), blue: placebo (P).
E: Titer distribution and median fecal phage titer in log10 pfu/g stool for the indicated treatment groups.