Table 3.
Quantitative diarrhea parameters in patients with microbiologically confirmed E. coli diarrhea treated with Microgen or T4-like phage cocktail or placebo.
| Confirmed E. coli infections (n = 69) | Day 1 | Day 2 | Day 3 | Day 4 |
|---|---|---|---|---|
| Stool frequency: | ||||
| Placebo (n = 19) | 7.5 ± 3.4 (6.0–9.0) | 6.0 ± 3.1 (4.6–7.4) | 6.3 ± 4.5 (4.3–8.3) | 4.8 ± 3.9 (3.0–6.6) |
| Microgen (n = 22) | 6.3 ± 4.1 (4.6–8.0) | 5.3 ± 2.9 (4.1–6.5) | 4.2 ± 2.5⁎ (3.2–5.2) | 4.6 ± 5.1 (2.5–6.7) |
| T4-like phage (n = 28) | 6.6 ± 4.1 (5.1–8.1) | 5.8 ± 4.3 (4.2–7.4) | 5.0 ± 3.9 (3.6–6.4) | 4.3 ± 3.2 (3.1–5.5) |
| Stool weight: | ||||
| Placebo (n = 19) | 514 ± 444 (314–714) | 422 ± 360 (260–584) | 350 ± 352 (192–508) | 316 ± 280 (190–442) |
| Microgen (n = 22) | 433 ± 265 (322–544) | 276 ± 196 (194–358) | 278 ± 213 (189–367) | 293 ± 279 (176–410) |
| T4-like phage (n = 28) | 406 ± 480 (228–584) | 344 ± 321 (225–463) | 280 ± 284 (175–385) | 280 ± 345 (152–408) |
| ORS need: | ||||
| Placebo (n = 19) | 393 ± 261 (276–510) | 341 ± 341 (188–494) | 333 ± 319 (190–476) | 283 ± 373 (115–451) |
| Microgen (n = 22) | 328 ± 220 (236–420) | 252 ± 294 (129–375) | 192 ± 256 (85–299) | 216 ± 280 (99–333) |
| T4-like phage (n = 28) | 330 ± 289 (223–437) | 281 ± 368 (137–425) | 293 ± 438 (131–455) | 201 ± 312 (85–317) |
Values are means ± standard deviation (95% CI, confidence interval).
Days 1–4 of treatment.
Stool frequency: number of bowel movements per day for the indicated day of hospitalization.
Stool weight: stool weight in g per patient and the indicated 24 h period.
ORS: volume of ORS in ml needed per indicated day to correct dehydration.
n = number of patients per specified group.
⁎
P = 0.07 in unpaired Student t-test, for all other comparisons P > 0.1.