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. 2016 Mar 3;9:17. doi: 10.3389/fnmol.2016.00017

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Copyright © 2016 Li, Su, Wang, Zhao, Liao, Wang and Si.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of subchronic treatment of MK-801 (0.1, 0.2, 0.4 mg/kg, once daily) during adolescence (PND 29–42) on relative density of CB⁺ interneurons that co-express somatostatin (SST) in the superficial and deep layers of the cingulate subregion 24 h after drug cessation. Representative confocal images show both superficial and deep layers of the cingulate subregion immunostained for DAPI, CB and SST in animals receiving either vehicle or MK-801 (0.2 mg/kg) treatment. Interneurons in superficial (white box) and deep (yellow box) layers are shown in the bottom row. CB⁺/SST⁺ interneurons are labeled with arrowhead. n = 4 per group. *p < 0.05, **p < 0.01 compared with the vehicle group.