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. 2016 Mar 3;9:17. doi: 10.3389/fnmol.2016.00017

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Copyright © 2016 Li, Su, Wang, Zhao, Liao, Wang and Si.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Investigation of the mechanisms of MK-801-induced reductions in GABAergic interneurons. Effects of subchronic treatment of MK-801 (0.1, 0.2, 0.4 mg/kg, once daily) during adolescence (PND 29–42) on the density of GAD65/67⁺ neurons (A) and the protein levels of GAD65/67 (B) the density of apoptotic cells (C) the expression levels of two apoptosis-related molecules (Bax and Bcl-2) and their ratio (D) and expression levels of three CBPs. (E) Representative sections show GAD65/67-immunoreactive neurons (A) and apoptotic cells (C, arrowhead-labeled), respectively, in the cingulate subregion in animals receiving either vehicle or MK-801 (0.2 mg/kg) treatment. n = 4 per group for cell counts and n = 5 per group for other results. *p < 0.05, **p < 0.01 compared with the vehicle group. Cg, cingulate cortex; PrL, prelimbic cortex; IL, infralimbic cortex.