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. 2016 Mar 3;6:22425. doi: 10.1038/srep22425

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Copyright © 2016, Macmillan Publishers Limited

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(a) Out-of plane X-ray diffraction of oriented POPC membranes containing cortisone. (b) Top: scaled electron densities across the axis perpendicular to the bilayer for 0 mol% and 5 mol% cortisone. Bottom: the difference of these curves shows a positive peak at Å, indicating the position of cortisone, and a negative peak at Å due to the thinning of the membrane. The difference curve from the MD simulations at 5 mol% is included for comparison. The slight disagreement in peak position and width between experiment in simulation is likely due to bilayer undulations²⁸. An example of is shown as an inset. (c) The lamellar spacing, , and the head-head distance, , as a function of cortisone concentration as determined from diffraction experiments. (d) Scattering along for the oriented membrane samples. Additional peaks, which appear for cortisone concentrations >20 mol%, can be indexed by crystalline cortisone. (e) The integrated intensities for the crystalline cortisone peak observed at Å⁻¹ as a function of azimuthal angle ϕ. (f) Unit cell of the observed cortisone crystallites, as determined from the in-plane Bragg peaks.

Inline graphic — (a) Out-of plane X-ray diffraction of oriented POPC membranes containing cortisone. (b) Top: scaled electron densities across the axis perpendicular to the bilayer for 0 mol% and 5 mol% cortisone. Bottom: the difference of these curves shows a positive peak at Å, indicating the position of cortisone, and a negative peak at Å due to the thinning of the membrane. The difference curve from the MD simulations at 5 mol% is included for comparison. The slight disagreement in peak position and width between experiment in simulation is likely due to bilayer undulations²⁸. An example of is shown as an inset. (c) The lamellar spacing, , and the head-head distance, , as a function of cortisone concentration as determined from diffraction experiments. (d) Scattering along for the oriented membrane samples. Additional peaks, which appear for cortisone concentrations >20 mol%, can be indexed by crystalline cortisone. (e) The integrated intensities for the crystalline cortisone peak observed at Å⁻¹ as a function of azimuthal angle ϕ. (f) Unit cell of the observed cortisone crystallites, as determined from the in-plane Bragg peaks.