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. 2016 Mar 3;7:38. doi: 10.3389/fphar.2016.00038

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Copyright © 2016 De Fazio, Spisni, Cavazza, Strillacci, Candela, Centanni, Ricci, Rizzello, Campieri and Valerii.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Geraniol (Ge-OH) modulates cyclooxygenase-2 (COX-2) expression in vivo in colon specimens during the acute phase (day 25). COX-2 mRNA expression was evaluated by real-time PCR. COX-2 mRNA levels were normalized against β-actin mRNA and relative expressions were calculated using the 2-2ΔCt formula. COX-2 overexpression induced by DSS was significantly reduced by Ge-OH treatment. Data are expressed as mean ± SEM of at least three replicates (n = 6). ^*P < 0.05 compared to DSS group. ^#P < 0.05 compared to CTRL group.