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. 2016 Mar 3;6:22606. doi: 10.1038/srep22606

Figure 1. Perinatal eNRG1 administration results in higher burst activity of adult nigral dopamine neurons in vivo.

Figure 1

(a) Typical single unit traces with similar firing rates are displayed for control and eNRG1-pretreated mice. The bursting periods are marked with black lines. (b) A recording site marked with Pontamine sky blue. Aq: aqueduct, IPF: interpeduncular fossa, ml: medial lemniscus, SNr: substantial nigra pars reticulata. Mean firing rates (c), spikes within bursts (SWB) (d), burst frequency (e), burst duration (f) and coefficient of variation (CV) of interspike intervals (g) are plotted for controls and eNRG1-pretreated mice. Dopaminergic neurons from eNRG1-pretreated mice exhibited a greater proportion of total spikes within bursts (d) as well as more bursts, whereas mean firing rates did not differ from dopaminergic neurons in control mice (n = 38 cells from 7 control mice and n = 53 cells from 11 eNRG1-pretreated mice). *p < 0.05, **p < 0.01, Mann–Whitney U test.