Figure 4.
Protection of hu-PBL-NOG mice against HTLV-I by hu-LAT-27. The Mitomycin C (MMC)-treated HTLV-I-infected ILT-M1 (1 × 106 cells) was mixed with freshly isolated PBMCs (2 × 106 cells) from healthy donor in a final volume of 50 µL and then were directly injected into the spleens of NOG mice. MAbs (0.5 mg each: lower panels) or control IgG (0.5 mg each: upper panels) was inoculated i.v. one hour before cell transplantation. Fourteen days after cell transplantation, mice were sacrificed, blood was collected by cardiocentesis, and human lymphocytes were recovered from the spleen. The bisector indicated in all panels showed tax negative edge of histogram.