Figure 2.

Transient IgM autoreactivity during acute IM. HEp-2 immunofluorescence staining was performed with serum derived from IM patients and control subjects from both cohorts. (A) HEp-2 positive vimentin-like staining of one representative IM patient; (B) Summary table of elevated IgM reactivity to vimentin during acute IM observed in both cohorts; (C) and (D) ELISA detection of anti-vimentin IgM autoantibodies in IM patients was significantly elevated compared to controls in both cohorts; (E) Longitudinal samples collected from IM patients in cohort 1 revealed decrease in anti-vimentin IgM antibodies six months post diagnosis of acute IM.