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. 2016 Mar 3;10:10. doi: 10.3389/fnint.2016.00010

Figure 2.

Figure 2

(A) Extracellular lactate levels expressed as % of baseline ± SEM (mean of the first two samples set 100%) within the dorsal hippocampus of freely moving rats measured by microdialysis. Rats were injected bilaterally into the dorsal hippocampi with either vehicle or 1,4-dideoxy-1,4-imino-D-arabinitol (DAB, 300 pmol). Dialysate fractions were collected 10 min prior to training (0 min, ↑) to determine baseline levels and collection then continued every 10 min for 50 min. Training significantly increased lactate levels over baseline (*p < 0.05) and this effect was abolished by DAB (#p < 0.05; n = 4/group). (B) Long-term memory retention expressed as mean latency values ± SEM in seconds (s) tested 24 h (Test 1) as well as 7 days (Test 2) after training. Vehicle, DAB (300 pmol), or DAB (300 pmol) + L-lactate (100 nmol) was administered bilaterally into the dorsal hippocampus 15 min prior to inhibitory avoidance (IA) training (*p < 0.05; n = 12/group). Adapted from Suzuki et al. (2011).