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. 2016 Mar 3;10:47. doi: 10.3389/fncel.2016.00047

Figure 4.

Figure 4

Armcx3 effects on neural differentiation depend on its mitochondrial localization. (A,C,E) Representative transverse sections of chick neural tubes from embryos electroporated at HH stage 12 with the indicated plasmids and processed and analyzed 48hpe as described in Figure 2. In contrast to the full length Armcx3 (see Figure 2), the overexpression of a non-mitochondrial truncated version of Arcmx3 (Armcx3Δ1-12) did not induce apparent changes in the lateral distribution of progenitors (A–D) or modify the percentage of Sox2/GFP or HuCD/GFP positive cells. (F) Similarly, Armcx3Δ1-12 overexpression has no impact on the HuCD + area (G,H), the width of Tuj-1 positive region (G,H), or the percentage of electroporated cells positive for Tuj-1 (I). Data represent the mean ± s.e.m.