Figure 5.

Armc10 overexpression reduces progenitors proliferation. Representative transverse sections of chick neural tubes from embryos electroporated at HH stage 12 with the indicated plasmids and processed and analyzed 24hpe as described in Figure 1. As is seen with Arcmx3, Armc10 protein is localized at the mitochondria of neural progenitors as indicated by its colocalization with the mitochondrial marker CoxIV (A). (C) Schematic representation illustrating the distributions of the VZ and MZ at HH12+24hpe. Armc10 overexpression did not induce changes in the lateral distribution of electroporated neural progenitors (B,E) or in the percentage of GFP/Sox2 or GFP/HuCD positive cells (D,F,G). However, it induced a reduction in the percentage of PH3/GFP and BrdU/GFP positive cells (H,I). Data represent the mean ± s.e.m. (^*p < 0.05).