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. 2016 Mar 3;6:22338. doi: 10.1038/srep22338

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(A)ALK-EML4 fusion found in sample #A59. ALK and EML4 break at chr2 29446561 and chr2 42523152, respectively. Then the minus stand of EML4 was reverse conjoined to ALK. (B) Confirmation of ALK-EML4 fusion by FISH. (C) MET amplification found in sample #P46. Gene region from 116435940 to 116436719 on chromosome 7 had a copy number of three. (D) Confirmation of MET amplification by immunohistochemistry.